The aim of this work was to investigate the performance and stability of the perovskite La0.5Sr0.5CoO3-delta, as a potential catalyst precursor, for the synthesis gas production by partial oxidation of methane. For this purpose, the catalytic activity of La0.5Sr0.5CoO3-delta was studied as a function of the temperature, flow rate and feed composition. In addition, its stability with the time-on-stream and redox cycles was also explored. Before and after testing, the catalyst precursor was characterized by X-ray diffraction, SEM-EDX and specific surface area (BET). The results evidenced a remarkable catalytic activity due to the stability of the cobalt, which is in a highly disperse state, in its reduced state. The CH4 conversion and the CO and H-2 selectivities were enhanced with the increase of redox cycles. Finally, the precursor was totally regenerated to the initial perovskite structure under a specific thermal treatment. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.