Hydrogen, within the so called Hydrogen Economy, has the potential to become the energy carrier of the future which could change entirely the energy industry. It could help to change to a more reliable, efficient and environmentally friendly energy sector. Hydrogen Economy is based on different technologies which are related to the scientific and industrial sectors. Thus, all equipment included within hydrogen technologies are in an experimental stage or in a too early market, safety being one of the research lines followed in the design and use of these equipment and devices. This paper includes the design and implementation of different building works to have a place to operate in a safe way electrolyzers and fuel cell systems that belong to a research project in which Centro Nacional del Hidrogeno (CNH2) is taking part in its current facilities. Because of working with hydrogen, the whole design was considered from the point of view of the potential to generate explosive atmospheres. Copyright (C) 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.