The performance of membrane electrode assembly (MEA) prepared with PtRu nanoparticles supported on a mesoporous carbon as anode catalyst are presented and compared against PtRu synthesized over Vulcan carbon. Polarization and power curves were obtained using 1 M methanol aqueous solution at the anode and O-2 at the cathode. The mesoporous carbon supported catalyst shows peak power of 40 mW cm(-2) and 67 mW cm(-2) at 30 degrees C and 60 degrees C respectively, that is, 15-30% higher than the Vulcan supported catalyst, and exhibits a wider range of operating current. Moreover, an improvement in the mass transport is observed for the catalyst supported on mesoporous carbon, yielding a lower voltage drop at high current density. This behavior was confirmed by electrochemical impedance spectroscopy (EIS), where an increases of the Warburg coefficient value by a factor 3-4 for the catalyst supported on mesoporous carbon as compared with that supported on Vulcan, would indicate a more facile diffusion of methanol through the mesoporous carbon. Copyright (C) 2013, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.