In this paper is given a general formulation of electron transfer (ET) in the system where the conformational transitions are present. The conformation changes of the system were described as a classical telegraphic noise. In the work was assumed that electron transfer reaction can be completely interrupted by the fluctuation of the electronic coupling. A functional-integral approach to the dynamics of a two-state system was used. We have got exact analytical nonperturbative expression for the probability to find electron on donor at time t. We derived two limiting cases for the electron transfer-the nonadiabatic limit and the conformational-controlled adiabatic ET case.