The chemical interaction study of MgO-SiO2-B2O3 La2O3 (ML) glass with low and high-temperature electrolytes is reported as a function of different heating durations. The as prepared diffusion couples with high-temperature and low temperature electrolytes have been heat-treated at 850 degrees C and 800 degrees C, respectively, for 5, 100 and 750 h. The heat-treated diffusion couples have been characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray dot mapping and electron probe microanalysis (EPMA). Micro-structural analysis of diffusion couples completely precludes the presence of any unwanted oxides and reaction products at the interface. The glass has shown good bonding characteristics and absence of delamination particularly with yttria stabilized zirconia (YSZ). Efforts have also been made to understand the interfacial reaction by considering different theoretical parameters associated with ML glass. Copyright (c) 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.