In case of fuel cell vehicle application, hydrogen exhaust is inevitable. The catalytic combustion of hydrogen is considered as one of the most efficient counter-methods. The difficulty is to improve low temperature catalytic behavior of the catalyst and decrease air resistance of the reaction bed. This paper reported a kind of mesoporous ceramic coating monolithic Pt-based catalyst (Pt/Ce0.6Zr0.4O2/MgAl2O4/cordierite) prepared from only inorganic salt and alkali according to the generalized acid base theory. The coating and catalysts were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), and N-2-adsorption. The results showed the coating had typical spinel crystallization structure and high surface area (more than 200 m(2) g(-1)). The Ce-Zr oxide modification increased the surface area and improved the oxygen storage capacity. And the results of hydrogen catalytic combustion indicated that this monolithic catalyst had high activity for hydrogen combustion reaction, which could quickly start up even at 263 K. For low temperature catalytic combustion of hydrogen, the initial reaction temperature, H-2 concentration, and space velocity were very important parameters. Copyright (C) 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.