A new equation with high precision has been proposed to investigate the fuel consumption characteristics of hydrogen-fueled vehicles. This new equation is designed to calculate the hydrogen consumption of vehicles under high pressure condition. Based on data from the American National Standards Institute (ANSI), error of hydrogen consumption calculated using the new equation is less than 0.5% when hydrogen storage pressure ranges from 0.5 to 70 MPa at 298 K. When storage pressure ranges from 0.1 to 50 MPa and temperature is 48-398 K, error is still less than 0.5%, with reference to data from the National Institute of Standards and Technology (NIST). Therefore, the new equation provides a simple yet effective way of estimating the cruising range of hydrogen-fueled vehicles. Crown Copyright (C) 2011, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.