Flow boiling experiments were conducted in copper microchannels with two different footprints of 25 mm x 25 mm and 20 mm x 10 mm. The channels, having nominal dimensions of 300 mu m width and 1200 pm depth with a surface roughness of 2 mu m (Ra), were fabricated by wire-cut EDM. De-ionized water was used as the coolant fluid. Experimental data was plotted on Taitel-Dukler flow regime map to predict the flow boiling regimes existing within the channels under different operating conditions. An 'M' shaped variation of the local heat transfer coefficient was obtained with respect to the exit vapor quality and the heat transfer mechanism was explained based on the existent flow boiling regime. High speed visualizations were shown to validate the explanation. Assessment of the predictive accuracy of the classical two-phase heat transfer correlations from literature revealed that regime based correlations when applied to the respective regimes can better predict the heat transfer in microchannels. The occurrences of instabilities were observed and their effect on heat transfer was also studied. (C) 2013 Elsevier Ltd. All rights reserved.