Alkali-surfactant-polymer (ASP), surfactant-polymer (SP) and alkali-polymer (AP) flooding have been recognized as potentially effective Chemical Enhanced Oil Recovery (EOR) techniques. The alkali in ASP or AP flooding blends interacts with formation minerals, markedly with anhydrite in the case of eolian deposits. As a result, water chemistry after the injection of an engineered chemical blend is unlikely to be governed only by fluid-fluid interactions at reservoir conditions. To investigate rock-fluid interactions, Berea and available rock samples from an oil-bearing Minnelusa reservoir in Wyoming, an eoalian formation, are used in coreflooding experiments. Further, a robust ASP blend at optimal salinity was designed for the DC Minnelusa crude oil. Secondary waterflooding, tertiary ASP injection, polymer drive and finally a brine flush are subsequently completed in coreflooding experiments. Oil recovery, pressure drop, surfactant concentration, pH, and viscosity are measured during or immediately after each experiment; water chemistry is analyzed in effluent samples. Findings show the potential of the chemical blends to improve oil recovery significantly under low-salinity conditions (<12,000 ppm) of the DC formation at present. Also, rock type recovery dependence highlights the importance of rock-fluid interactions. The results of this study can be applied to reservoirs at low salinity conditions and/or where anhydrite is present. (C) 2012 Elsevier Ltd. All rights reserved.