The oxidation state of the surfaces of titanium-based biomaterials strongly depends on their previous history. This factor affects the titanium wettability and it probably conditions the success of the implanted biomaterials. However, the separate role of the pollution and oxidation states of metallic titanium surfaces remains still controversial. To elucidate this, it is required to standardize the initial surface state of titanium in terms of roughness and surface chemistry, and then, to monitor its wettability after the corresponding treatment. In this work, we studied finely polished surfaces of commercially pure titanium (cpTi) which were subjected to cleaning surface treatments. X-Photoelectron spectroscopy was used to characterize the surface chemistry and the oxide film thickness. The contact angle hysteresis in underwater conditions was measured with the growing/shrinking captive bubble method, which allowed for mimicking the real conditions of implantable devices. The water wettability of smooth cpTi surfaces was stabilized with weak thermal oxidation (230 degrees C, 30 min). The osteoblastic cell response of the stabilized and non-stabilized cpTi surfaces was analyzed. Although the oxidation and pollution states were also stabilized and normalized, no correlation was observed between the stable response in wettability of titanium and its cell adhesion.