The European Parliament stated that high-efficiency cogeneration is a Community priority given the potential benefits of cogeneration with regard to saving primary energy and reducing emissions. According to this position, the performance of many micro-cogeneration systems have been assessed from an energy and environmental point of view. However, in the most part of cases, the assessments have been performed by using technical data from manufacturers and/or experimental results measured during steady-state operation, without considering the inefficiencies related to the transient periods; in addition, few works have been devoted to analyze the system operation from an exergy-based point of view. In this paper the electric load-following operation of an internal combustion engine based micro-cogeneration unit with 6.0 kW as nominal electric output has been experimentally investigated in electric load-following operation during a 24 h dynamic test with the application of a realistic daily load profile representing the Italian domestic non-HVAC electric demand for a multi-family house of five dwellings. The measured data have been compared with those that would be associated with servicing the building with electricity from the central electric grid and heat from a natural gas fired boiler from an energy, exergy and environmental points of view. (C) 2013 Elsevier Ltd. All rights reserved.