Intense research is being done on the highly efficient and selective conversion of glucose into high value-added chemicals. For this purpose, a functional electrocatalytic reactor was employed to efficiently produce gluconic acid (GA) and glucaric aicd (GLA) from glucose under mild condition. The reactor was assembled by a nano-MnO2 loading tubular porous titanium (Ti) electrode (MnO2/Ti electrode) as anode and a stainless steel mesh as cathode. The effects of MnO2 loading, pH value, glucose concentration (C-0glucos), reaction temperature, residence time and current density on the glucose oxidation were investigated during the reactor operation. The results indicated that 98% conversion of glucose and 98% total selectivity to GA and GLA (43% selectivity to GA and 55% selectivity to GLA) were obtained by electrocatalysis using the MnO2/Ti electrode (4.98 wt% MnO2 loading) under the operating conditions of the reactor: an aqueous glucose solution of 50.5 mmol L-1, a reaction temperature of 30 degrees C, a residence time of 19 min, a current density of 4 mA cm(-2) and pH of 7. By further increasing the current density to 6 mA cm(-2), 99% conversion of glucose and 99% total selectivity to GA and GLA (15% selectivity to GA and 84% selectivity to GLA) were obtained. The excellent performance of the controllable oxidation of glucose is mainly attributed to the electrochemical oxidation and convection-enhanced mass transfer as well as to the timely removal of the desired products in the reactor. (C) 2014 Elsevier Ltd. All rights reserved.