NHR-200, an integrated nuclear reactor with thermal power of 200 MW is developed by INET. Coupling NHR-200 with three kinds of desalination processes, low-temperature horizontal tube MED-TVC, high-temperature stacked VTE-MED and a hybridization of reverse osmosis and MED have been investigated and compared. The capacities of the fresh water production are 107,500 m(3)/d 160,000 m(3)/d, and 250,000 m(3)/d respectively. This paper presents the main features of the reactor, interface consideration between the reactor and desalination plant, and the preliminary economic analysis results. The hybrid RO/MED process showed the best economic competition. (C) 2012 Elsevier B.V. All rights reserved.