Triple differential cross section measurements for the electron-impact ionization of the highest occupied molecular orbital of tetrahydrofuran (THF) are reported. Experimental measurements were performed using the (e,2e) technique in asymmetric coplanar kinematics with an incident electron energy of 250 eV and an ejected electron energy of 20 eV. With the scattered electrons being detected at -5 degrees, the angular distribution of the ejected electrons was observed. These measurements are compared with calculations performed within the molecular 3-body distorted wave (M3DW) model, and against previous measurements on THF and tetrahydrofurfuryl alcohol to further understand the role that kinematics and structure play in electron-impact ionization. (C) 2013 Elsevier B.V. All rights reserved.