Ion-based statistical associating fluid theory (SAFT2), coupled with van der Waals and Platteeuw theory, is applied to predict methane, ethane, and propane hydrate dissociation conditions in the presence of ethanol, ethyleneglycol (MEG), and glycerol, as well as mixed MEG and electrolyte solutions, including NaCl, KCl, and CaCl2. Ion-based SAFT2 is found to give accurate predictions for these complex systems. The effects of temperature and concentration on hydrate dissociation conditions are well captured. (c) 2012 Elsevier Ltd. All rights reserved.