Resolution of DL-glutamic acid was used as a model system to demonstrate how solute exchange between two crystallizers in a novel hybrid system results in both high purity and high yield. Circulating streams from two crystallization vessels were passed on opposite sides of a hollow-fiber membrane module, which allowed solute interchange but restricted transfer of crystals between the two vessels. Protocols were developed that resulted in process outcomes that were more realistic than had been achieved in previous work without sacrificing purity or yield of crystal products. Experimental results demonstrate important links among the transport rate through the membrane, allowable cooling rate, product purity, and yield. (C) 2012 Elsevier Ltd. All rights reserved.