In the context of biofuel production from marine microalgae, anaerobic digestion has the potential to make the process more sustainable and to increase energy efficiency. However, the use of salt-containing microalgae organic residues entails the presence of salts which inhibits methanogenesis. The search for suitable anaerobic microbial consortium adapted to saline conditions can boost the anaerobic conversion into methane. The anaerobic digestion performance of three different anaerobic microbial consortia was assessed in batch tests at different salinities between 15 and 150 g L-1 and for three successive substrate additions. After an acclimation period, the methane (CH4) yield of the halophilic methanogens at 35 g L-1 of salinity was close to the reference value without salt addition. Above 75 g L-1 of salinity, methanogenesis was considerably slowed down. The results underline that methane production from halophilic sediment can be envisaged and promoted for practical application at a seawater concentration. (C) 2014 Elsevier Ltd. All rights reserved.