This research article investigates the effect of flow improvers on the rheological and microscopic properties of a waxy crude oil of the western oil field of India, since the application of flow improvers is the most economic way for controlling the flow assurance problems associated with the production, handling, and processing of waxy crude oils. In this work, hexatriethanolamine mono oleate, which is a flow improver, was synthesized in the laboratory. The effect of this synthesized flow improver and a commercial pour point depressant on the waxy crude oil was studied thoroughly and their experimental results were compared. It was observed that both flow improvers have the potential to improve the flow behavior of this crude oil significantly, and the synthesized flow improver has shown better performance than the commercial flow improver.