SFE-CO2 is a novel, promising, environmentally benign and inexpensive extracting method developed over the past few years to overcome environmental problems encountered due to the use of conventional solvents. One component (the extractant) is separated from another (the matrix) using SCF-CO2 as the extracting solvents. This method is widely used for extracting heavy metals from environmental contaminant, bioactive compounds like antioxidants, plant medicine and natural products or remediating heavy metal contaminated soil by using good binding activity of SCF-CO2 to heavy metal ions. The major advantages of the use of SCF-CO2 as a solvent are its superior mass transfer properties, easy recycling and lack of secondary waste formation. We try to focus on the recent advances in SCF-CO2 extraction technology for heavy metal extraction. In this review, the mechanism, procedure, and application of heavy metal extraction by SCF-CO2 are summarized in a comprehensive manner and the factors affecting the extraction efficiency are analyzed. We try to provide some meaningful information about heavy metal extraction by SCF-CO2 and make it a preferable option in heavy metal treatments.