The performance of desiccant cooling systems has been increasingly addressed, with applications spanning from thermal comfort to gas-turbine air cooling. Desiccant systems are particularly suitable regarding the environmental impact, due to the absence of refrigerants with ozone-depleting properties. Moreover, the use of low-grade waste heat as the primary energy source also characterizes a low global warming potential, when compared to vapor compression systems. Under this scenario, this study demonstrates how desiccant ventilation cycles can be tuned for environmental conditions while maintaining the conditioned space within acceptable thermal comfort conditions. The analysis is based on a simple numerical procedure for desiccant cooling simulation in which the overall system operation is calculated from individual cycle components' characteristics. With the employed methodology, the conditioned space state is calculated for different environmental conditions and compared to a standard, previously set, comfort zone. The results show that, in addition to desiccant wheel performance, the effectiveness of evaporative coolers and the regenerator is of prime importance for achieving acceptable thermal comfort conditions.