The United States is in need of a new and more adaptive long-term strategy for spent nuclear fuel. In this communication, we outline the fundamental reasons why deep borehole disposal should receive more detailed investigation, alongside traditional shallow mined repositories. This potential solution is supported by advancing drilling technologies and an improving understanding of extremely long fluid residence times in deep bedrock. Radionuclide isolation is supported by verifiable and stable geologic barriers such as long transport distances to aquifers, low permeability, and reducing chemical conditions. The modular nature of implementing deep borehole disposal could offer unique programmatic and economic advantages. Experience with a pilot borehole program will be required to confirm the feasibility of drilling and emplacement operations, and key chemical and hydraulic conditions. (C) 2014 Elsevier Ltd. All rights reserved.