The perennial political and social upheavals in major oil-producing regions, the increasing energy demand from emerging economies, the global economic crisis and even environmental disasters, like the recent major oil spill in the Gulf of Mexico, all contribute to price fluctuations and escalations. Usually price instability affects the least-developed countries with the most fragile economies, like Ghana, the most. This paper gives a brief overview of the Ghanaian energy situation, describes the liquid biofuel production processes and examines the possibility of replacing some of the fossil fuels consumed annually, with locally produced renewable biofuels. Various scenarios for substituting different portions of petrol and diesel with biofuels derived from cassava and palm oil are examined. Based on 2009 crop production and fuel consumption data, replacement of 5% of both petrol and diesel with biofuels would require 1.96% and 17.3% of the cassava and palm oil produced in that year, respectively; while replacement of 10% of both fossil fuels would need 3.91% and 34.6% of the corresponding biofuels. Thus while petrol replacement could be initiated with little difficulty, regarding raw material availability, biodiesel would require enhanced palm oil production and/or oil supplement from other sources, including, potentially, jatropha. An implementation strategy is proposed. (C) 2011 Elsevier Ltd. All rights reserved.