A quartz fixed-bed, microreactor was successfully constructed for both the catalytic methanol-to-gasoline (MTG) and methanol-and-glycerol-to-gasoline (MGTG) processes. The reaction products were analyzed by gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC). Process variables of temperature and reaction time were studied to determine the effects on conversion rates, product yield, and ZSM-5 catalyst lifetime for both systems. Moreover, the factor of glycerol additions (10, 25, and 40% in methanol) was also investigated for the MGTG process. The MTG and MGTG generated oil phase showed a similar composition, mainly methylbenzenes, to regular gasoline, and composition changed as the reaction proceeded to favor heavier aromatics. In the MTG process, the best catalytic performance was achieved at 425 degrees C, at which the product yield and catalyst lifetime were 11.0 wt % and 20 h, respectively. Generally, the methanol conversion rate and the total liquid and organic-phase yield rates decreased with the reaction time at each temperature. In addition to gasoline-range aromatics, some oxygenates were also detected in the extracted aqueous phase from the MGTG process. The best MGTG catalytic performance was achieved at 500 degrees C with 10% glycerol in methanol, at which the product yield and catalyst lifetime were 14.9 wt % and 8 h, respectively. The higher glycerol content disfavored the production of aromatics but favored oxygenates. With an increasing reaction time at all reaction conditions; methanol and glycerol conversion rates were >= 99%.