The fatty acid methyl esters of vegetable oils and animal fats, more commonly known as biodiesel, represent a renewable, biodegradable, noninflammable, and low toxicity alternative to diesel. In this study, the Hansen solubility parameters (HSPs) and the interaction radius of the solute sphere (R-0) were determined for the biodiesel derived from soybean oil, coconut oil, palm oil, and castor oil, using 45 solvents and solvent mixtures. The values for the HSPs and R-0 obtained for the different biodiesels were soybean (15.03, 3.69, 8.92, and 11.33; MPa(1/2)); coconut (15.12, 3.99, 9.25, and 10.92; MPa(1/2)); palm (15.43, 5.28, 6.61, and 10.54; MPa(1/2)); and castor (16.10, 6.72, 9.11, and 11.78; MPa(1/2)). The HSPs of four biofuels were also determined using the average values of the fatty esters of each oil, calculated using group contribution. Subsequently, the solubilities of the biofuels were predicted using the van Krevelen-Hoftyzer, Greenhalgh, and Bagley approaches.