Chemistry Letters, Vol.43, No.2, 178-180, 2014
Propylphosphonic Anhydride-catalyzed Tandem Approach for Biginelli Reaction Starting from Alcohols
An efficient and highly convergent route to dihydropyrimidinones (DHPMs) has been developed by one-pot three-component oxidative cyclocondensation of a variety of alcohols, beta-ketoesters/beta-oxodithioester and urea in the presence of T3P (R)/DMSO. This new approach consistently has the advantage of tandem and good yields (65-88%).