Static high pressure treatment has become a gentle alternative in sterilization of fluids, but due to high costs, this technology is currently restricted to high-quality products. The innovative use of dynamic high pressure has the potential to overcome these restrictions as the introduction of additional process parameters allows for amplification of lethal effects on microorganisms. In addition, through the possibility to further convey the product during low-pressure periods, the dynamic treatment also enables quasi-continuous modes of operation, which opens a broader field of applications.