This article proposes a model-based direct adaptive proportional-integral (PI) controller for a class of nonlinear processes whose nominal model is input-output linearizable but may not be accurate enough to represent the actual process. The proposed direct adaptive PI controller is composed of two parts: the first is a linearizing feedback control law that is synthesized directly based on the process's nominal model and the second is an adaptive PI controller used to compensate for the model errors. An effective parameter-tuning algorithm is devised such that the proposed direct adaptive PI controller is able to achieve stable and robust control performance under uncertainties. To show the robust stability and performance of the direct adaptive PI control system, a rigorous analysis involving the use of a Lyapunov-based approach is presented. The effectiveness and applicability of the proposed PI control strategy are demonstrated by considering the time-dependent temperature trajectory tracking control of a batch reactor in the presence of plant/model mismatch, unanticipated periodic disturbances, and measurement noises. Furthermore, for use in an environment that lacks full-state measurements, the integration of a sliding observer with the proposed control scheme is suggested and investigated. Extensive simulation results reveal that the proposed model-based direct adaptive PI control strategy enables a highly nonlinear process to achieve robust control performance despite the existence of plant/model mismatch and diversified process uncertainties.