The influence of a gas-liquid chemical reaction on the interfacial area produced in a contactor is analyzed. Two different amines were used to capture carbon dioxide by chemical absorption. The effects of the operation time, the amine used, the concentration interval, and the gas flow rate on typical hydrodynamic parameters used in bubble columns such as the gas holdup and the Sauter mean diameter were investigated. These parameters were used to determine the interfacial area value. Significant influences on the gas-liquid interfacial area were detected, mainly caused by the reaction rate intensity, the physicochemical properties of the liquid phase, and the gas flow rate fed to the contactor.