A novel design of pilot-scale continuous flow pharmaceutical fixed-bed catalytic reactor has been developed. This incorporates in a structured manner the use of multiple catalytic monoliths (o.d. = 20 mm; L = 50 mm). O-2 was used as the oxidant (O-2/N-2 mixture) for the partial oxidation of benzyl alcohol to benzaldehyde, using Pt impregnated (2.5 and 2.7 wt%) carbon monoliths. Reactions were performed e.g. at liquid flow = 1 dm(3) h(-1); benzyl alcohol concentration = 1 kmol m(-3); T = 110 degrees C; P = 12 bar(g). A major breakthrough was the demonstration of the viability of this design at pilot-scale. (c) 2013 Elsevier B.V. All rights reserved.