단분산성 다공의 폴리아크릴로니트릴-에틸렌 글리콜 디메타크릴레이트 마이크로 겔의 제조 및 특성

김공수; 강석호; 김영식

Journal of the Korean Industrial and Engineering Chemistry, Vol.7, No.4, 777-786, August, 1996

Export Citation

단분산성 다공의 폴리아크릴로니트릴-에틸렌 글리콜 디메타크릴레이트 마이크로 겔의 제조 및 특성

Preparation and Characterization of Monodisperse Porous Poly (acrylonitrile-ethylene glycol dimethacrylate) Microgels

김공수, 강석호, 김영식

초록

Seed 중합 방법에 의하여 단분산성 다공의 폴리아크릴로니트릴-에틸렌글리콜 디메타크릴레이트 (PAN) 고분자 마이크로 겔이 제조되었다. PAN 마이크로 겔의 물리적인 특성을 모노머/seed와 희석제/모노머의 비율, 가교제의 농도 및 희석제의 종류에 따라 연구하였다. PAN 마이크로 겔의 입도 분포는 모노머/seed의 비율이 50 이하 일 때 단분산성을 나타냈으며, 가교제의 농도가 증가할수록 입자 내부의 미소 구체 (microsphere)의 크기가 작아져 더욱 밀집된 형태를 나타내기 때문에 입자의 비표면적이 증대되었다. 또한 희석제로 톨루엔을 사용하고 희석제/모노머의 비율이 1.0일 때 입자표면의 세공이 가장 발달되었다.

Uniform sized-porous poly(acrylonitrile-ethylene glycol dimethacrylate) (PAN) microgels were synthesized by seed polymerization using monodisperse polystyrene seed particles. The effect of weight ratios of monomer/seed (M/S) and diluent/monomer (DIM), concentration of crosslinking agent and the type of diluent was investigated on the formation of PAN microgels. The particle size distribution of PAN microgels was found to be monodisperse in that the weight ratio of M/S is less than 50. More porous microgels were formed and the interstices between small sized interior microspheres present inside of PAN microgels were also smaller with increasing crosslinking agent concentration. Well-developed pore structure was found to be in that weight ratio of D/M is 1 and toluene is used as a diluent.

[References]

Hoffmann M, Makromol. Chem., 174, 613 (1974)
Forget J, Booth C, J. Polym. Sci. B: Polym. Phys., 17, 1403 (1979)
Price C, Forget J, Booth C, Polymer, 18, 527 (1977)
Shahar M, Meshulam H, Margel S, J. Polym. Sci., 24, 203 (1986)
Klech CM, Li X, J. Pharm. Sci., 79, 999 (1990)
Rembaum R, Dreyer WJ, J. Polym. Sci., 208, 364 (1980)
Hoffman AS, Afrassiabi A, Dong LC, J. Control. Release, 4, 213 (1986)
Bae YH, Okano T, Hsu R, Makromol. Chem. Rapid Commun., 8, 481 (1987)
Kulin LI, Ellingsen T, Ugelstad J, J. Chromatogr., 514, 1 (1990)
Cheng CM, Vanderhoff JW, El-Asser MS, J. Polym. Sci., 30, 245 (1992)
Ogino K, Sato H, 일본고분자논문집, 46, 667 (1989)
Park TG, Hoffman AS, J. Biomed. Mater. Res., 24, 21 (1990)
Park TG, Hoffman AS, Biotechnol. Bioeng., 35, 152 (1990)
Gehrke SH, Andrews GP, Cussler EL, Chem. Eng. Sci., 41, 2153 (1986)
Freitas RFS, Cussler EL, Chem. Eng. Sci., 42, 97 (1987)
Kawaguchi H, hoshinon F, Ontsuka Y, Makromol. Chem. Rapid Commun., 7, 109 (1986)
Egawa H, Nakayama M, Nonaka T, Uemura K, J. Appl. Polym. Sci., 34, 1557 (1987)
Okubo M, Polym. Int., 30, 469 (1993)
Ugelstad J, Kaggerud KH, Hansen FK, Makromol. Chem., 180, 737 (1979)
Hattori, European Patent, Application, 190,886 (1986)
Hayashi S, Komatsu A, Hirai T, J. Polym. Sci., 27, 157 (1989)
Luymes AJ, McNulty W, J. Macromol., 23, 3104 (1990)
Galia M, Svec F, Frechet JM, J. Polym. Sci. A: Polym. Chem., 32(11), 2169 (1994)

[Referenced By]

[1] Hoffmann M, Makromol. Chem., 174, 613 (1974)

[2] Forget J, Booth C, J. Polym. Sci. B: Polym. Phys., 17, 1403 (1979)

[3] Price C, Forget J, Booth C, Polymer, 18, 527 (1977)

[4] Shahar M, Meshulam H, Margel S, J. Polym. Sci., 24, 203 (1986)

[5] Klech CM, Li X, J. Pharm. Sci., 79, 999 (1990)

[6] Rembaum R, Dreyer WJ, J. Polym. Sci., 208, 364 (1980)

[7] Hoffman AS, Afrassiabi A, Dong LC, J. Control. Release, 4, 213 (1986)

[8] Bae YH, Okano T, Hsu R, Makromol. Chem. Rapid Commun., 8, 481 (1987)

[9] Kulin LI, Ellingsen T, Ugelstad J, J. Chromatogr., 514, 1 (1990)

[10] Cheng CM, Vanderhoff JW, El-Asser MS, J. Polym. Sci., 30, 245 (1992)

[11] Ogino K, Sato H, 일본고분자논문집, 46, 667 (1989)

[12] Park TG, Hoffman AS, J. Biomed. Mater. Res., 24, 21 (1990)

[13] Park TG, Hoffman AS, Biotechnol. Bioeng., 35, 152 (1990)

[14] Gehrke SH, Andrews GP, Cussler EL, Chem. Eng. Sci., 41, 2153 (1986)

[15] Freitas RFS, Cussler EL, Chem. Eng. Sci., 42, 97 (1987)

[16] Kawaguchi H, hoshinon F, Ontsuka Y, Makromol. Chem. Rapid Commun., 7, 109 (1986)

[17] Egawa H, Nakayama M, Nonaka T, Uemura K, J. Appl. Polym. Sci., 34, 1557 (1987)

[18] Okubo M, Polym. Int., 30, 469 (1993)

[19] Ugelstad J, Kaggerud KH, Hansen FK, Makromol. Chem., 180, 737 (1979)

[20] Hattori, European Patent, Application, 190,886 (1986)

[21] Hayashi S, Komatsu A, Hirai T, J. Polym. Sci., 27, 157 (1989)

[22] Luymes AJ, McNulty W, J. Macromol., 23, 3104 (1990)

[23] Galia M, Svec F, Frechet JM, J. Polym. Sci. A: Polym. Chem., 32(11), 2169 (1994)