Two routes were used to produce Cu-Zr-Al/Al2O3 amorphous nanocomposite. First route included mechanical alloying of elemental powders mixture. In second route Cu60Zr40 alloy was synthesized by melting of Cu and Zr. Cu60Zr40 alloy was then ball milled with Al and CuO powder. It was not possible to obtain a fully amorphous structure via first route. The mechanical alloying of Cu60Zr40, Al and CuO powder mixture for 10 h led to the reaction of CuO with Al, forming Al2O3 particulate, and concurrent formation of Cu62Zr32Al4 amorphous matrix. The thermodynamical investigations on the basis of extended Miedema's model illustrated that there is a strong thermodynamic driving force for formation of amorphous phase in this system. Lack of amorphization in first route appeared to be related to the oxidation of free Zr during ball milling. (C) 2013 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.