화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.22, No.7, 717-724, July, 2014
DOI10.1007/s13233-014-2103-0  Export Citation
Fabrication of Microporous Chitosan/Silk Fibroin as a Scaffold Material Using Electron Beam
Salita Saengthong1, Thananchai Piroonpan2, Theeranan Tangthong3, and Wanvimol Pasanphan1, 4, †
  • 1Department of Applied Radiation and Isotopes, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand
  • 2Department of Materials Science, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand, Taiwan
  • 3Thailand Institute of Nuclear Technology (TINT), Ministry of Science and Technology, Nakhon Nayok, 26120, Thailand, Taiwan
  • 4Department of Materials Science, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand, Thailand
E-mail:
The aim of this study is to develop microporous material from silk fibroin (SF) and chitosan (CS) using electron beam-induced crosslinking technique. Poly(ethylene glycol) dimethacrylate (PEGDMA) was used as radiation crosslinking agent. Comparative studies were done using two different polymeric components, i.e., CS and CS/SF. An effect of irradiation dose on crosslinking density and swelling degree were investigated. The chemical structure and packing conformation of the obtained microporous materials were characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) techniques. The morphology and microstructure were assessed using scanning electron microscope (SEM). The PEGDMA crosslinked in a CS/SF system (CS-PEGDMA-SF) possessed greater inter-connected porous network than that in a single CS component (CS-PEGDMA). The gel fraction was ranging from 90% to 100% when the irradiation doses of 10-80 kGy were carried out. The swelling degree increased by means of gel fraction and irradiation dose. The pore size CS-PEGDMA-SF and CS-PEGDMA varied in the range of 0.80-1.35 μm and 8.07-16.32 μm, respectively depending on the irradiation doses. The fabricated scaffolds showed the porosity ranging from 21% to 94%. Taken together, CS-PEGDMA-SF microporous material from electron-beam irradiation would serve as a good promising scaffold for tissue engineering.
Keywords:chitosan;silk fibroin;PEGDMA;microporous;scaffold;crosslinking;electron beam.
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