Development of pH-Responsive Chitosan-Coated Mesoporous Silica Nanoparticles

Muhammad Gulfam; Bong Geun Chung

Macromolecular Research, Vol.22, No.4, 412-417, April, 2014

DOI10.1007/s13233-014-2063-4 Export Citation

Development of pH-Responsive Chitosan-Coated Mesoporous Silica Nanoparticles

Muhammad Gulfam, and Bong Geun Chung^{1, †}

Department of Bionano Technology, Hanyang University, Gyeonggi, 426-791, Korea
¹Department of Mechanical Engineering, Sogang University, Seoul, 121-742, Korea

E-mail:

We synthesized pH-responsive chitosan-coated mesoporous silica nanoparticles. The morphological characterization conveyed that the mesoporous silica was encapsulated within pH-responsive cationic chitosan. Further, the average diameter of chitosan-coated mesoporous silica nanoparticles was approximately 230 nm. The doxorubicin, an anticancer drug, was loaded into the cavities of mesoporous chitosan-coated silica nanoparticles. pH played an important role in regulating the release of doxorubicin from chitosan-coated mesoporous silica nanoparticles, indicating that 53% and 90% doxorubicin were released from chitosan-coated mesoporous silica nanoparticles within 48 h at pH 7.4 and pH 4.4, respectively. We also demonstrated the endocytosis of chitosan-coated mesoporous silica nanoparticles in MCF-7 breast cancer cells. Therefore, this chitosan-coated mesoporous silica nanoparticle could be a powerful tool for pH-responsive controlled release of the anticancer drug.

Keywords:pH-responsive chitosan;mesoporous silica nanoparticle;anticancer drug;controlled releas.

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[1] Stayton PS, Shimoboji T, Long C, Chilkoti A, Chen GH, Harris JM, Hoffman AS, Nature, 378(6556), 472 (1995)

[2] Roy D, Cambre JN, Sumerlin BS, Prog. Polym. Sci., 35, 278 (2010)

[3] Bhattarai N, Gunn J, Zhang M, Adv. Drug Deliv. Rev., 62, 83 (2010)

[4] Lin YS, Haynes CL, J. Am. Chem. Soc., 132(13), 4834 (2010)

[5] Slowing II, Trewyn BG, Lin VSY, J. Am. Chem. Soc., 129(28), 8845 (2007)

[6] Warren SC, Disalvo FJ, Wiesner U, Nat. Mater., 6(2), 156 (2007)

[7] Zhu Y, Shi J, Shen W, Dong X, Feng J, Ruan M, Li Y, Angew. Chem. Int. Ed., 44, 5083 (2005)

[8] Jiang X, Ward TL, Cheng YS, Liu J, Brinke CJ, Chem. Commun., 46, 3019 (2010)

[9] Zhu J, Tang J, Zhao L, Zhou X, Wang Y, Yu C, Small, 6, 276 (2010)

[10] Ashley CE, Carnes EC, Phillips GK, Padilla D, Durfee PN, Brown PA, Hanna TN, Liu JW, Phillips B, Carter MB, Carroll NJ, Jiang XM, Dunphy DR, Willman CL, Petsev DN, Evans DG, Parikh AN, Chackerian B, Wharton W, Peabody DS, Brinker CJ, Nat. Mater., 10(5), 389 (2011)

[11] Gary-Bobo M, Hocine O, Brevet D, Maynadier M, Raehm L, Richeter S, Charasson V, Loock B, Morere A, Maillard P, Garcia M, Durand JO, Int. J. Pharm., 423, 509 (2012)

[12] Cheng SH, Lee CH, Yang CS, Tseng FG, Mou CY, Lo LW, J. Mater. Chem., 19, 1252 (2009)

[13] Di Pasqua AJ, Sharma KK, Shi YL, Toms BB, Ouellette W, Dabrowiak JC, Asefa T, J. Inorg. Biochem., 102, 1416 (2008)

[14] Lin W, Huang YW, Zhou XD, Ma Y, Ma, Toxicol. Appl. Pharm., 217, 252 (2006)

[15] Sun L, Li Y, Liu X, Jin M, Zhang L, Du Z, Guo C, Huang P, Sun Z, Toxicol. In Vitro, 25, 1619 (2011)

[16] Napierska D, Thomassen LCJ, Rabolli V, Lison D, Gonzalez L, Kirsch-Volders M, Martens JA, Hoet PH, Small, 5, 846 (2009)

[17] Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, Zink JI, Nel AE, ACS Nano, 3, 3273 (2009)

[18] Liu R, Liao PH, Liu JK, Feng PY, Langmuir, 27(6), 3095 (2011)

[19] Jang JH, Choi YM, Choi YY, Joo MK, Park MH, Choi BG, Kang EY, Jeong B, J. Mater. Chem., 21, 5484 (2011)

[20] Deng Z, Zhen Z, Hu X, Wu S, Xu Z, Chu PK, Biomaterials, 32, 4976 (2011)

[21] Wu J, Su ZG, Ma GH, Int. J. Pharm., 315, 1 (2006)

[22] Wu J, Sailor M, Adv. Funct. Mater., 19(5), 733 (2009)

[23] Wan Y, Zhao DY, Chem. Rev., 107(7), 2821 (2007)

[24] Rejman J, Oberle V, Zuhorn IS, Hoekstra D, Biochem. J., 377, 159 (2004)

[25] Gulfam M, Kim J, Lee JM, Ku B, Chung BH, Chung BG, Langmuir, 28, 8216 (2012)

[26] Ge H, Hu Y, Jiang X, Cheng D, Yuan Y, Bi H, Yang C, J. Pharm. Sci., 91, 1463 (2002)

[27] Song SW, Hidajat K, Kawi S, Chem. Commun., 4396 (2007)

[28] Danhier F, Feron O, Preat V, J. Control. Release, 148, 135 (2010)