High dispersiveness of an aerosol, short time for cloud generation, and uniform distribution in a room are substantial parameters that have to be taken into account in the development of disinfectant, decontaminating, and fire-extinguishing aerosols. To obtain greater homogeneity of an aerosol cloud, it has been suggested to additionally employ a centrifugal atomizer, which enables a relatively wide spray angle, in the design of a pulsed-type aerosol generator. A physicomathematical model for an explosive-type centrifugal atomizer is suggested herein. Results of parametric studies of the model are summarized which establish dependences of the aerosol dispersiveness, spray angle, and mass flow rate upon dimensionless parameters characterizing geometric properties of the sprayer. The physicomathematical model allows the sprayer characteristics to be selected in order to obtain aerosol media with a priori specified parameters. Experimental results with respect to the dynamics of the filling of an experimental vessel with an aerosol produced by the explosive-type centrifugal atomizer are presented. Comparison of the experimental and theoretical data indicates the adequacy of the physicomathematical model proposed.