The present investigation elucidates the role of pulse-cleaning parameters and filter media designs on the extent of dust emission and emitted particle characteristics during industrial pollution control using the pulse-jet filtration process. The study is followed by statistical analysis based on L-8 (2(7)) orthogonal design methodology. The experimental study shows that the dust concentration in clean gas increases with an increase in pulse pressure and pulse duration, whereas it decreases with an increase in pulse cycle. However, the contribution of pulse pressure and pulse duration is much higher than the impact of pulse cycle. In regard to the impact of filter media design, a higher level of bag height (which also implies lower air-to-cloth ratio) and lower level of seamline spacing can lead to higher outlet emissions at the transitory stage. The role of pulse pressure, bag height, and seamline spacing are found to be very significant in regulating fine particles in the emission (PM2.5) and, consequently, the aforesaid factors affect all volume particles diameters (D-10, D-50, and D-97) and weight mean particles diameter D (4, 3) of particles in bulk.