Activities of precious metals and selected transition metal oxide catalysts for methyl isobuthyl ketone(MIBK) combustion were measured, and among the catalysts tested, Pd/Al₂O₃ and CuCr₂BO₄/Al₂O₃ were found most effective. Kinetic experiments were conducted using an integral reactor for Pd and CuCr₂O₄ catalysts. In the temperature range of 403-443 K, activation energies for Pd and CuCr₂O₄ catalyst on MIBK oxidation were estimated to be 9.2 and 11.4Kca1/gmol, respectively. Steady state responses of a monolith catalytic incinerator to changes in operating conditions or monolith design parameters have been examined on the basis of one dimensional mathematical model. Calculations showed that, under typical operating conditions, the catalyst system is operating under mass transfer controlled conditions. Higher conversion efficiencies were obtained with higher inlet temperatures and higher MIBK concentrations, and with low gas velocities. Monoliths having higher channel densities offer superior performances. It was implicated that channel size and shape can have significant influences on the conversion and temperature profiles along the monolith channels.