This work focuses on the solution to the problem of model predictive control of time delay processes with both integrating and stable modes and model uncertainty. The controller is developed for the practical case of zone control and input target tracking. The method is based on a state-space model that is equivalent to the analytical form of the step response model corresponding to the system transfer function. Here, this model is extended to the time delay system. The proposed controller is evaluated through simulation of the of two control reactor systems and the results confirms the robustness of the proposed approach. (c) 2013 Elsevier Ltd. All rights reserved.