Three types of steam and autothermal reforming systems using methanol or ethanol are addressed in the Aspen Plus environment. Regarding the stand-alone energy design, the external energy supply is completely replaced by the waste heat recovery system. The optimal operating condition not only ensures the maximum hydrogen yield, but the maximum waste heat recovery can also be achieved. An autothermal reforming system using methanol is verified to achieve the lower hydrogen production cost as well as lower energy loss than other designs. To explore a simplistic single-input single-output (SISO) control structure, the closed-loop autotune variation (ATV) tests and the PID control settings are demonstrated by Aspen Dynamics. Finally, simulations show that the water flow manipulation could reject small unknown disturbances to ensure the no offset and stable output regulation.