The solubility of nifedipine (NIF) in binary mixtures of ethanol (EtOH) + water and propylene glycol (PG) + water at 293.2, 298.2, 303.2, 308.2, and 313.2 K was measured. The Jouyban-Acree model and its combination with van't Hoff equation was used to predict the solubility of NIF in the mixed solvents at different temperatures. The solubility of NIF in EtOH + water mixtures have a maximum at 0.90 mass fraction of EtOH, but the solubility of NIF in PG + water reaches to the maximum value in neat PG. Both mixtures (EtOH + water and PG + water) have a maximum solubility at 313.2 K. A mean relative deviation (MRD) for the fitted data to the Jouyban-Acree model of 8.1% and for combined method of 7.4% was obtained. The predicted MRDs for the solubility data using previously trained models were 38.8%, 43.0%, and 43.9%, and the MRD for predicted density value was 7.3%.