Catalytic wet air oxidation (CWAO) of aqueous bisphenol (BPA) solution was studied in a continuous-flow trickle bed reactor in the presence of titanate nanotube-based catalysis. These active metal free solids were prepared by alkaline hydrothermal synthesis followed by heat treatment at temperatures ranging from 300 to 700 degrees C, so that they would have varying physicochemical properties. The aim of the study Was to investigate the removal efficiency of titanate. nanotube-based catalysts used in the CWAO process to remove toxicity and estrogenicity of BPA at a very short space time of 0.6 min.g(CAT).g(-1). In addition, noncatalytic BPA degradation in the presence of Inert SiC particles was also performed As a result, significantly higher estrogenicity and toxic effects Of the liquid phase sample compared to the catalytic oxidation experiments were observed. Complete removal of estrogenicity and high reduction of toxicity from aqueous solution were achieved at 210 degrees C over 0.5 g of catalyst that had been annealed at 600 degrees C.