Computational fluid dynamics-discrete element method (CFD-DEM) coupled approach was employed to simulate the solid suspension behavior in a Rushton stirred tank with consideration of transitional and rotational motions of millions of particles with complex interactions with liquid and the rotating impeller. The simulations were satisfactorily validated with experimental data in literature in terms of measured particle velocities in the tank. Influences of operating conditions and physical properties of particles (i.e., particle diameter and density) on the two-phase flow field in the stirred tank involving particle distribution, particle velocity and vortex were studied. The wide distribution of particle angular velocity ranging from 0 to 10(5) r .min(-1) is revealed. The Magnus force is comparable to the drag force during the particle movement in the tank. The strong particle rotation will generate extra shear force on the particles so that the particle morphology may be affected, especially in the bio-/polymer-product related processes. It can be concluded that the CFD-DEM coupled approach provides a theoretical way to understand the physics of particle movement in micro-to macro-scales in the solid suspension of a stirred tank.