Chemistry Letters, Vol.42, No.10, 1163-1165, 2013
Synthesis of Alkylated Nitriles by [RuHCl(CO)(PPh3)(3)]-catalyzed Alkylation of Acetonitrile Using Primary Alcohols
Alkylation reaction of acetonitrile using primary alcohols is effectively catalyzed by [RuHCl(CO)(PPh3)(3)] in the presence of K3PO4 as a base. Both benzylic and non-benzylic alcohols coupled with acetonitrile to give alkylated nitriles in good yields.