Our atom-by-atom deposition method has been used to prepare hetero-tri-atomic clusters of Au (1) Pd (2) and Au (2) Pd (1) in polyaniline as isolation matrix. The sequence in which individual atoms are added affects the final structure of the cluster. Because of the uniquely defined point of attachment of the cluster to the PANI, isomers such as PANI-Pd-Au-Pd, PANI-Au-Pd-Pd and PANI-Pd-Pd-Au have been created. It is shown that the latter has much higher activity towards electrooxidation of n-propanol in alkaline medium than the first two. In fact, its activity is even higher than that of the most active homo-clusters PANI-Au (6) and PANI-Pd (2) . The observed results are in good agreement with few available theoretical calculations of the HOMO-LUMO gap energy of these structures.