Density and refractive index data at (298.15, 303.15, and 308.15) K, and speed of sound at 298.15 K in the binary mixtures of 2-ethoxyethanol with dimethyl sulfoxide, N,N’-dimethylformamide, and N,N’-dimethylacetamide have been measured over the entire mixture compositions. These data have been used to compute the excess molar volume, changes in molar refractivity, and isentropic compressibility of the mixtures. The results are fitted to the Redlich-Kister polynomial equation to estimate the binary coefficients and the standard errors. Furthermore, the experimental results are used to study the nature of the binary interactions in these mixtures.