생물고분자로 이루어진 저독성 흡수제의 팽윤거동

정진희; 김진; 이기영; Jin Hee Jung; Jin Kim; Ki-Young Lee

Polymer(Korea), Vol.37, No.4, 478-485, July, 2013

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생물고분자로 이루어진 저독성 흡수제의 팽윤거동

Swelling Behavior of Low Toxic Absorbent Based on Biopolymer

정진희, 김진, 이기영 ^{1, †}

전남대학교 신화학소재공학과
¹전남대학교 응용화학공학부 & 촉매연구소

Jin Hee Jung, Jin Kim, and Ki-Young Lee^{1, †}

Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju 500-757, Korea
¹Faculty of Applied Chemical Engineering& The Research Institute for Catalysis, Chonnam National University, Gwangju 500-757, Korea

E-mail:

초록

본 연구에서는 식품첨가물로 승인되어 있는 생물고분자 물질을 이용하여 신속팽윤성과 고흡수성을 갖는 하이드로젤을 제조하고 팽윤특성을 분석하였다. 하이드로젤을 제조하는 과정에서 기포발생제를 이용하여 기공을 형성시켜 기존 하이드로젤의 팽윤성 향상을 시도하였고 각 하이드로젤의 평형 팽윤도, 팽윤속도 및 세포독성을 비교하였다. Alginate hydrogel에서는 digital microscope 관찰을 통해 수백 μm 크기의 열린 채널로 다공성 구조를 관찰하였으며 제조된 모든 하이드로젤들은 poly(acrylic acid)에 비해 높은 세포생존율을 보였다.

In this study, hydrogels with fast swelling and high absorbent properties were prepared using biopolymers approved as a food additive and their swelling properties were characterized. To improve the swelling properties of conventional hydrogels, we formed gas bubbles using a foaming agent in the process of preparing hydrogels and characterized in terms of equilibrium swelling ratio, swelling kinetics and cytotoxicity. In particular, alginate hydrogels observed by a digital microscope have an open-pore channels structure with the sizes of hundreds micrometers. Also, the cell viability of all hydrogels were found to be much higher than that of poly(acrylic acid).

Keywords:fast swelling;high absorbent;biopolymer;low cytotoxicity.

[References]

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Gemeinhart RA, Park H, Park K, Polym. Adv. Technol., 11, 617 (2000)
Khang G, Lee I, Lee HB, Lee SJ, Polym. Sci. Technol., 13(1), 4 (2002)
Nelson WL, Cretcher LH, J. Am. Chem. Soc., 51, 1914 (1929)
Zimmermann U, Klock G, Federlin K, Haning K, Kowaslski M, Bretzel RG, Horcher A, Entenmann H, Siebers U, Zekorn T, Elecrophoresis., 13, 269 (1992)
Morris ER, Rees DA, Robinson C, J. Molecular Biology., 138, 349 (1980)
Guiseley KB, Stanley NP, Whitehous PA, Carrageenan in handbook of watersoluble gums and resins, McGraw-hill, New York (1980)
Richardson RK, Goycoolea FM, Carbohydr. Polym., 24, 233 (1994)
Axelos M, Garnier C, Thibault JF, Renard C, Progress in Biotechnology., 14, 35 (1996)
Liu PF, Zhai ML, Li JQ, Peng J, Wu JL, Radiat. Phys.Chem., 68, 771 (2003)
Bajpai SK, Bajpai M, Sharma L, J. Macromol. Sci. Pure Appl. Chem., 43, 507 (2006)
Sriamornsak P, Kennedy RA, J. Pharmaceutics., 434, 72 (2006)
Mosmann T, J. Immunol. Methods., 65, 55 (1983)
Theil J, Maurer G, Fluid Phase Equilibria., 165, 224 (1999)
Eiselt P, Yeh J, Latvala RK, Shea LD, Mooney DJ, Biomaterials., 21, 1921 (2000)
Atkins P, Paula JD, Physical Chemistry, Oxford University, New York, 648 (2010)
Singh B, Pal L, J. Eur. Polym., 44, 3222 (2008)
Crank J, Park GS, Diffusion in Polymers, Academic Press, New York, 377 (1968)
Alfrey T, Gurnee EF, Lloyd WG, J. Polym. Sci., Part C., 12, 249 (1966)
Ritger PL, Peppas NA, J. Contr. Rel., 5, 37 (1987)
Kim B, Korean Chem. Eng. Res., 43(2), 299 (2005)
Kim WJ, Rao VNM, Smith CJB, J. Food Sci., 43, 572 (1978)
Alonso-Mougan M, Meijide F, Jover A, Rodriguez-Nunez E, Vazquez-Tato J, J. Food Eng., 55, 123 (2002)
Sriamornsak P, Kennedy RA, J. Pharmaceutics., 358, 205 (2008)

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[1] Omidian H, Rocca JG, Park K, J. Contr. Rel., 102, 3 (2005)

[2] Gemeinhart RA, Park H, Park K, Polym. Adv. Technol., 11, 617 (2000)

[3] Khang G, Lee I, Lee HB, Lee SJ, Polym. Sci. Technol., 13(1), 4 (2002)

[4] Nelson WL, Cretcher LH, J. Am. Chem. Soc., 51, 1914 (1929)

[5] Zimmermann U, Klock G, Federlin K, Haning K, Kowaslski M, Bretzel RG, Horcher A, Entenmann H, Siebers U, Zekorn T, Elecrophoresis., 13, 269 (1992)

[6] Morris ER, Rees DA, Robinson C, J. Molecular Biology., 138, 349 (1980)

[7] Guiseley KB, Stanley NP, Whitehous PA, Carrageenan in handbook of watersoluble gums and resins, McGraw-hill, New York (1980)

[8] Richardson RK, Goycoolea FM, Carbohydr. Polym., 24, 233 (1994)

[9] Axelos M, Garnier C, Thibault JF, Renard C, Progress in Biotechnology., 14, 35 (1996)

[10] Liu PF, Zhai ML, Li JQ, Peng J, Wu JL, Radiat. Phys.Chem., 68, 771 (2003)

[11] Bajpai SK, Bajpai M, Sharma L, J. Macromol. Sci. Pure Appl. Chem., 43, 507 (2006)

[12] Sriamornsak P, Kennedy RA, J. Pharmaceutics., 434, 72 (2006)

[13] Mosmann T, J. Immunol. Methods., 65, 55 (1983)

[14] Theil J, Maurer G, Fluid Phase Equilibria., 165, 224 (1999)

[15] Eiselt P, Yeh J, Latvala RK, Shea LD, Mooney DJ, Biomaterials., 21, 1921 (2000)

[16] Atkins P, Paula JD, Physical Chemistry, Oxford University, New York, 648 (2010)

[17] Singh B, Pal L, J. Eur. Polym., 44, 3222 (2008)

[18] Crank J, Park GS, Diffusion in Polymers, Academic Press, New York, 377 (1968)

[19] Alfrey T, Gurnee EF, Lloyd WG, J. Polym. Sci., Part C., 12, 249 (1966)

[20] Ritger PL, Peppas NA, J. Contr. Rel., 5, 37 (1987)

[21] Kim B, Korean Chem. Eng. Res., 43(2), 299 (2005)

[22] Kim WJ, Rao VNM, Smith CJB, J. Food Sci., 43, 572 (1978)

[23] Alonso-Mougan M, Meijide F, Jover A, Rodriguez-Nunez E, Vazquez-Tato J, J. Food Eng., 55, 123 (2002)

[24] Sriamornsak P, Kennedy RA, J. Pharmaceutics., 358, 205 (2008)