화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.37, No.4, 462-469, July, 2013
Export Citation
카테킨이 함유된 창상피복제용 하이드로젤의 개발
Development of Hydrogel Containing Catechin for Wound Dressing
김진, 조은비, 이기영1, †
  • 전남대학교 신화학소재공학과
  • 1전남대학교 응용화학공학부 & 촉매연구소
Jin Kim, Eun Bi Cho, and Ki-Young Lee1, †
  • Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju 500-757, Korea
  • 1Faculty of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University, Gwangju 500-757, Korea
E-mail:
초록
Catechin(CTEC)은 천연항산화제로 알려져 있고 항염증에 효과적이며 피부 창상치료제로 응용되고 있다. 이 연구는 β-cyclodextrin(β-CD)으로 나노입자화한 CTEC을 poly(vinyl alcohol)(PVA)/pectin(PT) 조성의 하이드로젤에 첨가하였다. 피부상처의 재상피화를 위해 CTEC과 β-CD을 분자복합(molecular complex) 방법에 의해 나노입자 제조를 수행하였다. 하이드로젤에 첨가된 CTEC 나노입자는 250±17.5 nm이며, 입자 내 CTEC의 담지 효율은 처음 첨가량의 74%가 담지되었음을 확인하였다. CTEC는 하이드로젤 필름으로부터 pH7.4와 pH5.5 버퍼에서 72시간 동안 각각 86.51±3.14%와 35.95±2.14%의 방출을 보였다. 창상치료 실험에서 CTEC 나노입자가 적재된 PVA/PT 조성의 하이드로젤은 CTEC이 함유된 도포형 젤보다 빠른 치유력을 관찰할 수 있었다.
Catechin (CTEC) is well-known as a very powerful antioxidant, containing the effects of anti-inflammation and skin wound healing. In this study, CTEC/β-cyclodextrin (β-CD) nanoparticles were incorporated into poly(vinyl alcohol) (PVA)/pectin (PT) hydrogel. The composite was designed for the induction of re-epithelializaton in skin wound. CTEC/β-CD nanoparticles were prepared by a molecular complex method. The size of the CTEC nanoparticles formed in the hydrogel was in the range of 250±17.5 nm. The incorporation efficiency of CTEC in the nanoparticles was 74%. The cumulative amounts of CTEC released from the hydrogel containing CTEC nanoparticles in the buffers of pH7.4 and 5.5 were 86.51±3.14% and 35.95±2.14% of total CTEC loaded in the hydrogel within 72 h, respectively. Also, in the wound healing test, the CTEC nanoparticles-loaded PVA/PT hydrogel showed faster healing of the wound made in rat dorsum than the CTEC gel.
Keywords:catechin;herbal medicine;transdermal delivery;re-epithelialization.
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