Preparation and release properties of electrospun poly(vinyl alcohol)/poly(ε-caprolactone) hybrid nanofibers: Optimization of process parameters via D-optimal design method

Payam Zahedi; Iraj Rezaeian; Seyed Hassan Jafari; Zeinab Karami

Macromolecular Research, Vol.21, No.6, 649-659, June, 2013

DOI10.1007/s13233-013-1064-z Export Citation

Preparation and release properties of electrospun poly(vinyl alcohol)/poly(ε-caprolactone) hybrid nanofibers: Optimization of process parameters via D-optimal design method

Payam Zahedi¹, Iraj Rezaeian^{1, †}, Seyed Hassan Jafari^{1, 2, †}, and Zeinab Karami¹

¹School of Chemical Engineering, College of Engineering, University of Tehran, P. O. Box 11155-4563, Tehran, Iran
²Nano-Biomedicine Center of Excellence, Nano-Science and Nano-Technology Research Center, University of Tehran, Tehran, Iran

E-mail:,

The main purpose of this work was to develop biomedical electrospun nanofibrous mats based on a poly(vinyl alcohol)/poly(ε-caprolactone) (80/20) hybrid with a defined drug release rate using tetracycline hydrochloride as a model drug. The electrospinning process parameters, such as polymer solution concentration, distance between injecting syringe tip/collector, voltage, injected flow rate and the polyvinyl alcohol cross-linking time were optimized via a D-optimal design method for a suitable nanofiber diameter with an optimal drug release rate. The morphology of nanofibers and their mean diameters were studied by a scanning electron microscopy technique. The results showed that the mean diameters of nanofibers were significantly reduced after drug loading. The swelling, weight loss and biodegradability of nanofibers samples investigated by FTIR were also determined. Two main mechanisms via penetration and erosion were evaluated. In vitro drug release in a phosphate buffer environment at pH=7.2 for the samples demonstrated that the polymer type and hydrophilic nature of the polymer/drug system is very effective in the kinetics and mechanism of drug release. Hybridization of poly(vinyl alcohol)/poly(ε-caprolactone) with a known ratio showed to be a suitable and useful method in the electrospinning of nanofibers samples for superior control of the drug release rate. Finally, nanofibrous mats of polyvinyl alcohol and polyvinyl alcohol/poly(ε-caprolactone) hybrid (80/20) had much better drug release rate characteristics for tetracycline hydrochloride as a model drug compared with cast film samples loaded with the same drug.

Keywords:nanofiber;poly(vinyl alcohol) (PVA);poly(ε-caprolactone) (PCL);hybrid;response surface methodology;drug release;tetracycline

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[Referenced By]

[1] Lu JY, Norman C, Abboud KA, Ison A, Inorg. Chem. Commun., 4, 459 (2001)

[2] Yan E, Haung Z, Xin Y, Zhao Q, Zhang W, Mater. Lett., 60, 2969 (2006)

[3] Vitchuli N, Shi Q, Nowak J, Caldwell JM, Breidt F, Bourham M, McCord M, Zhang X, Sci. Technol. Adv. Mater., 12, 1 (2011)

[4] Park KE, Jung SY, Lee SJ, Min BM, Park WH, Int. J. Biol. Macromol., 38, 165 (2006)

[5] Kim C, Cho YJ, Yun WY, Ngoc BTN, Yang KS, Chang DR, Lee JW, Kojima M, Kim YA, Endo M, Solid State Commun., 142, 20 (2007)

[6] Ding B, Kimura E, Sato T, Fujita S, Shiratori S, Polymer, 45(6), 1895 (2004)

[7] Xu XL, Zhuang XL, Chen XS, Wang XR, Yang LX, Jing XB, Macromol. Rapid Commun., 27(19), 1637 (2006)

[8] Moghe AK, Gupta BS, Polym. Rev., 48, 353 (2008)

[9] Sun B, Duan B, Yuan XY, J. Appl. Polym. Sci., 102(1), 39 (2006)

[10] Ding B, Kim HY, Lee SC, Shao CL, Lee DR, Park SJ, Kwag GB, Choi KJ, J. Polym. Sci. B: Polym. Phys., 40(13), 1261 (2002)

[11] Zong XH, Kim K, Fang DF, Ran SF, Hsiao BS, Chu B, Polymer, 43(16), 4403 (2002)

[12] Raymond HM, Montgomery DC, Response Surface Methodology: Process and Product Optimization Using Designed Experiments, John Wiley and Sons Inc., New York, 2002.

[13] Yordem OS, Papila M, Menceloglu YZ, Mater. Des., 29, 34 (2008)

[14] Sukigara S, Gandhi M, Ayutsede J, Micklus M, Ko F, Polymer, 45(11), 3701 (2004)

[15] Gu SY, Ren J, Vancso GJ, Eur. Polym. J., 41, 2559 (2005)

[16] Kenawy ER, Bowlin GL, Mansfield K, Layman J, Sympson DG, Sanders EH, Wnek GE, J. Control. Release, 81, 57 (2002)

[17] Ignatious F, Baldoni JM, WO Patent 0154667 (2001).

[18] Zahedi P, Karami Z, Rezaeian I, Jafari SH, Mahdaviani P, Abdolghaffari AH, Abdollahi M, J. Appl. Polym. Sci., 124(5), 4174 (2012)

[19] Khil MS, Cha DI, Kim IS, Bhattarai NB, J. Biomed. Mater. Res. B, 67, 675 (2005)

[20] Zhang Y, Lim CT, Ramakrishna S, Haung ZM, J. Mater. Sci. -Mater. Med., 16, 933 (2005)

[21] Zamani M, Morshed M, Varshosaz J, Jannesari M, Eur. J. Pharm. Biopharm., 75, 179 (2010)

[22] Taepaiboon P, Rungsardthong U, Supaphol P, Nanotechnology, 17, 2317 (2006)

[23] Thompson CJ, Chase GG, Yarin AL, Reneker DH, Polymer, 48(23), 6913 (2007)

[24] Costa P, Lobo JMS, Eur. J. Pharm. Biopharm., 13, 123 (2001)

[25] Zeng J, Yang L, Liang Q, Zhang X, Guan H, Xu X, Chen X, Jing X, J. Control. Release, 105, 43 (2005)

[26] Heredia-Corvera BE, Gonzalez-Azcorra SA, Rodriguez-Gattorno G, Lopez T, Ortiz-Islas E, Oskam G, Sci. Adv. Mater., 1, 63 (2009)

[27] Breda SA, Jimenez-Kairuz AF, Manzo RH, Olivera ME, Int. J. Pharm., 371, 106 (2009)

[28] Jannesari M, Varshosaz J, Morshed M, Zamani M, Int. J. Nanomed., 6, 993 (2011)

[29] Rosenberg R, Sevenney W, Seigel S, Dan N, Mol. Pharmacol., 4, 943 (2007)