Simulated moving bed (SMB) technology has attracted more and more attention in recent decades. The simulated moving bed (SMB) technology on optimal utilization of naphtha resource was studied in this paper. A simulated moving bed equipped with 16 columns was used to separate normal paraffins from naphtha. The effects of temperature (T), switching time (ts), extract oil flow rate (LAD), feed flow rate (LF), and desorbent flow rate (LD) on the separation performance were investigated, and the desorbent recycle process was simulated by Aspen Plus. The results showed that the optimal conditions for simulated moving bed were operation temperature (T) of 170 degrees C, switching time (ts) of 900 s, extract oil flow rate (LAD) of 10 mL/min, feed flow rate (LF) of 5 mL/min, and desorbent flow rate (LD) of 20 mL/min. Through the SMB and the desorbent recycle system, the purity of the de-solvent extract oil (DEO) reached 98% and the purity of the de-solvent raffinate oil (DRO) reached 92%, which were the high-quality feed for the ethylene cracking process and the catalytic reforming process, respectively.