Liquid-liquid equilibria (LLE) for tetraethylene glycol + heptane or + decalin and tetraethylene glycol + decane, + benzene, or + ethylbenzene over a temperature range of 293-330.5 K were used to estimate the interaction parameters between a new solvent group (tetraethylene glycol) and the main groups of CH2 (paraffinic > CH2), ACH (aromatic greater than or equal to CH), ACCH(2) (aromatic CCH2) and CHNA (condensed naphthenic CH)as a function of temperature. The estimated interaction parameters of these groups have been used with other interaction parameters present in the literature to compare calculated values with the experimental LLE equilibrium measurements.