Vapor liquid equilibrium (VLE) data for binary systems of 2-methyl-1-butanol with ethylbenzene and xylene isomers are isobarically obtained with a modified Rose still at 101.33 kPa, as well as for the quinary system of 2-methyl-1-butanol + ethylbenzene + xylene isomers. The binary VLE data are considered to be thermodynamically consistent according to the Herington method and the point-to-point test. Taking the nonideality of the vapor phase into consideration, the activity coefficients are calculated. All systems show positive deviation from ideality. The VLE data are correlated using the nonrandom two-liquid (NRTL), universal quasichemical activity coefficient (UNIQUAC), and Wilson models. The calculated vapor-phase compositions and temperature agree well with the experimental values. The obtained model parameters of the binary systems are used to predict the VLE data for the quinary system. The results indicate that these three models allow a good prediction of the phase equilibrium for the quinary system.